J06.9 Acute upper respiratory tract infection, unspecified J10 Influenza caused by an identified influenza virus Z54 Convalescent state Z73.0 Fatigue Z73.3 Stressful condition, not elsewhere classified
Pharmacological group
Vitamin preparation
Pharmacological action
Ascorbic acid (vitamin C) is not formed in the human body, but comes only from food.
Pharmacological effects: in quantities significantly exceeding the daily requirement (90 mg), has almost no effect, with the exception of quick fix symptoms of hypo- and vitamin deficiency (scurvy).
Physiological functions: is a cofactor in some hydroxylation and amidation reactions - it transfers electrons to enzymes, providing them with a reducing equivalent. Participates in the reactions of hydroxylation of proline and lysine residues of procollagen with the formation of hydroxyproline and hydroxylysine (post-translational modification of collagen), oxidation of lysine side chains in proteins with the formation of hydroxytrimethyllysine (in the process of kartinite synthesis), oxidation folic acid to folinic acid, drug metabolism in liver microsomes and hydroxylation of dopamine to form norepinephrine.
Increases the activity of amidating enzymes involved in the processing of oxytocin, antidiuretic hormone and cholecystokinin. Participates in steroidogenesis in the adrenal glands;
Restores Fe 3+ to Fe 2+ in the intestines, promoting its absorption. The main role in tissues is participation in the synthesis of collagen, proteoglycans and other organic components of the intercellular substance of teeth, bones and capillary endothelium.
In low doses (150-250 mg/day orally) it improves the complexing function of deferoxamine in chronic intoxication with iron preparations, which leads to increased excretion of the latter.
Ascorbic acid is actively involved in many redox reactions and has a nonspecific general stimulating effect on the body. Increases the body's adaptive abilities and its resistance to infections; promotes regeneration processes.
Pharmacokinetics
Absorbed in the gastrointestinal tract (mainly in the jejunum). With an increase in dose to 200 mg, up to 140 mg (70%) is absorbed; with a further increase in dose, absorption decreases (50-20%). Plasma protein binding - 25%. Gastrointestinal diseases (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic infestation, giardiasis), consumption of fresh fruit and vegetable juices, alkaline drinking reduce the absorption of ascorbic acid in the intestine.
The normal concentration of ascorbic acid in plasma is approximately 10-20 mcg/ml, body reserves are about 1.5 g when taking daily recommended doses and 2.5 g when taking 200 mg/day. The time to reach Cmax after oral administration is 4 hours.
Easily penetrates into leukocytes, platelets, and then into all tissues; highest concentration achieved in glandular organs, leukocytes, liver and lens of the eye; penetrates the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficient conditions, the concentration in leukocytes decreases later and more slowly and is considered as best criterion deficiency estimates than plasma concentrations.
Metabolized primarily in the liver into deoxyascorbic acid and further into oxaloacetic acid and ascorbate-2-sulfate.
Excreted by the kidneys, through the intestines, with sweat, breast milk unchanged and in the form of metabolites.
When high doses are prescribed, the rate of elimination increases sharply. Smoking and drinking ethanol accelerate the destruction of ascorbic acid (conversion into inactive metabolites), sharply reducing reserves in the body.
Excreted during hemodialysis.
Prevention and treatment of hypo- and vitamin deficiency C;
Conditions of increased need for ascorbic acid;
Period of artificial feeding and intensive growth;
Unbalanced diet;
Increased mental and physical stress;
The period of convalescence after serious illnesses;
Alcoholism;
Burn disease;
Feverish state against the background of acute respiratory diseases, acute respiratory viral infections;
Long-term chronic infections;
Nicotine addiction;
Stressful state;
Postoperative period, pregnancy (multiple, due to nicotine or drug addiction);
Chronic intoxication with iron preparations (as part of complex therapy with deferoxamine);
Idiopathic methemoglobinemia.
Thrombophlebitis;
Tendency to thrombosis;
Diabetes mellitus;
Sucrase/isomaltase deficiency, fructose intolerance,
glucose-galactose malabsorption;
Increased sensitivity.
WITH caution: hyperoxalaturia, renal failure, hemochromatosis, thalassemia, polycythemia, leukemia, sideroblastic anemia, glucose-6-phosphate dehydrogenase deficiency, sickle cell anemia, progressive malignant diseases.
If any side effects you should stop taking the drug and consult a doctor.
From the side of the central nervous system: headache, feeling of fatigue, with prolonged use of large doses - increased excitability of the central nervous system, sleep disturbances.
From the outside digestive system: irritation of the gastrointestinal mucosa, nausea, vomiting, diarrhea, stomach cramps.
From the endocrine system: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria).
From the urinary system: when used in high doses - hyperoxalaturia and formation urinary stones and calcium oxalate.
From the outside cardiovascular system: thrombosis, when used in high doses, increased blood pressure, development of microangiopathy, myocardial dystrophy.
Allergic reactions: skin rash; rarely - anaphylactic shock.
Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.
Others: hypovitaminosis, feeling of heat, with long-term use of large doses - sodium (Na +) and fluid retention, metabolic disorders of zinc (Zn 2+), copper (Cu 2+).
Overdose
Symptoms: when taking more than 1 g/day, heartburn, diarrhea, difficulty urinating or red coloration of urine, and hemolysis are possible. (in patients with glucose-6-phosphate dehydrogenase deficiency).
Treatment: symptomatic, forced diuresis.
Special instructions
Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor kidney function and blood pressure
With long-term use of large doses, inhibition of the function of the pancreatic insular apparatus is possible, so it must be regularly monitored during treatment.
In patients with high iron levels in the body, ascorbic acid should be used in minimal doses.
Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process.
Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity, lactate dehydrogenase).
Impact on the ability to drive vehicles and operate machinery
Ascorbic acid does not affect the speed of psychomotor reactions when driving a car or working with precision mechanisms.
Use during pregnancy and breastfeeding
The minimum daily requirement for ascorbic acid in the II-III trimesters of pregnancy is about 60 mg.
The minimum daily requirement during lactation is 80 mg. A maternal diet containing adequate amounts of ascorbic acid is sufficient to prevent vitamin C deficiency in infant(it is recommended that a nursing mother not exceed the maximum daily requirement for ascorbic acid).
Drug interactions
Increases the concentration of benzylpenicillin and tetracyclines in the blood; at a dose of 1 g/day increases the bioavailability of ethinyl estradiol.
Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron); may increase iron excretion when used concomitantly with deferoxamine.
Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinks reduce absorption and absorption.
When used simultaneously with ASA, the urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by approximately 30%.
Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the secretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood.
Increases the overall clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body.
Quinoline drugs (fluoroquinolones, etc.), calcium chloride, salicylates, corticosteroids, when used for a long time, deplete ascorbic acid reserves.
When used simultaneously, it reduces the chronotropic effect of isoprenaline.
Long-term use or use in high doses may interfere with the disulfiram-ethanol interaction.
In high doses, it increases the renal excretion of mexiletine.
Barbiturates and primidone increase the excretion of ascorbic acid in the urine.
Reduces the therapeutic effect of antipsychotics (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.
The drug is taken orally after meals.
For prevention:adults 0.05-0.1 g (1-2 tablets)/day, children from 5 years old - 0.05 g (1 tablet)/day.
For treatment: adults 0.05-0.1 g (1-2 tablets) 3-5 times/day, children from 5 years old- 0.05-0.1 g (1-2 tablets) 2-3 times/day.
At pregnancy and lactation- 0.3 g (6 tablets)/day for 10-15 days, then 0.1 g (2 tablets)/day.
Storage conditions and shelf life
Store the drug in a dry place, protected from light at a temperature not exceeding 25°C. Keep out of the reach of children. Shelf life - 1 year 6 months. Do not use after the date indicated on the package
Release from pharmacies
The drug is approved for use as an over-the-counter product.
One dragee contains
active substance - ascorbic acid (vitamin C) 50 mg,
excipients – sucrose (sugar), starch syrup, wheat flour, talc, food flavoring “Lemon”, sunflower oil, beeswax.
Description
Ball-shaped dragee from white to light cream color
Pharmacotherapeutic group
Vitamins. Ascorbic acid in its pure form. Ascorbic acid.
ATX code A11GA01
Pharmacological properties
Pharmacokinetics
Absorbed in the small intestine. With an increase in dose to 200 mg, up to 140 mg (70%) is absorbed; with a further increase in dose, absorption decreases (50-20%). Connection with blood plasma proteins -25%. Diseases of the gastrointestinal tract (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic infestation, giardiasis), consumption of fresh fruit and vegetable juices, alkaline drinking reduce the absorption of ascorbonate in the intestine.
The normal concentration of ascorbic acid in blood plasma is approximately 10-20 mcg/ml; body reserves are about 1.5 g when taking daily recommended doses and 2.5 g when taking 200 mg/day. The maximum concentration (Tmax) after oral administration is 4 hours. Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye; deposited in the posterior lobe of the pituitary gland, adrenal cortex, ocular epithelium, cells of the seminal glands of the ovaries, liver, spleen, pancreas, lungs, kidneys, intestinal wall, heart, muscles, thyroid gland; penetrates the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and blood plasma. In deficiency states, the concentration of ascorbic acid in leukocytes decreases later and more slowly and is therefore considered as a more reliable criterion for assessing deficiency than the concentration of ascorbic acid in blood plasma. Metabolized mainly in the liver, into deoxyascorbic acid and further into oxaloacetic and diketogulonic acids. It is excreted by the kidneys, through the intestines, with sweat, and breast milk in the form of unchanged ascorbate and metabolites. When high doses are prescribed, the rate of elimination increases sharply. Smoking and drinking ethanol accelerates the destruction of ascorbic acid (conversion into inactive metabolites), sharply reducing its reserves in the body.
Excreted during hemodialysis.
Pharmacodynamics
Ascorbic acid is a vitamin that is not formed in the human body, but comes only with food. Participates in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, and the synthesis of steroid hormones; increases the body's resistance to infections, reduces vascular permeability, reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid. Participates in the metabolism of phenylalanine, tyrosine, folic acid, norepinephrine, histamine, iron, utilization of carbohydrates, synthesis of lipids, proteins, carnitine, immune reactions, hydroxylation of serotonin, enhances the absorption of non-heme iron. It has antiplatelet and pronounced antioxidant properties.
Maintains the colloidal state of the intercellular substance and normal capillary permeability. Regulates immunological reactions (activates the synthesis of antibodies, C3 component of complement, interferon), promotes phagocytosis, increases the body's resistance to infections. Inhibits the release and accelerates the degradation of histamine, inhibits the formation of prostaglandins and other inflammatory mediators.
Indications for use
Prevention, treatment of hypo- and avitaminosis of vitamin C
With an increased need for vitamin C in the body during
active growth in children, pregnancy, breastfeeding
With increased physical and mental stress, fatigue, stressful conditions
During the recovery period after long and serious illnesses
Directions for use and doses
Orally, for preventive purposes, 50 mg - 100 mg (1 - 2 tablets) per day; during pregnancy and lactation - 300 mg for 10-15 days (3 tablets), then - 100 mg (2 tablets) per day, children aged 6 years and older - 50 mg - 100 mg (1 - 2 tablets) per day day.
WITH therapeutic purpose: adults 50 mg-100 mg (1-2 tablets) 3-5 times a day, children over 6 years old 50 mg-100 mg (1-2 tablets) 2-3 times a day.
The duration of treatment depends on the nature and course of the disease and is prescribed by a doctor.
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Side effects
Headache, feeling tired
With long-term use of large doses - increased excitability
CNS, sleep disorder
Irritation of the gastrointestinal mucosa, nausea, vomiting,
diarrhea, stomach cramps
Increased blood pressure, development of microangiopathies
Inhibition of the function of the pancreatic insular apparatus
(hyperglycemia, glycosuria)
Reduced capillary permeability and deterioration of tissue trophism, thrombosis when taking high doses
Allergic reactions: skin rash, rarely - anaphylactic shock
Contraindications
Hypersensitivity to the components of the drug
Thrombophlebitis
Tendency to thrombosis
Diabetes mellitus
Children under 6 years old
Increased blood clotting
Progressive malignant diseases
Hyperoxalaturia
Kidney failure
Hemochromatosis
Thalassemia
Glucose-6-phosphate dehydrogenase deficiency
Hyperoxaluria and formation of urinary stones from calcium oxalate, damage to the glomerular apparatus of the kidneys
Thrombocytosis, hyperprothrombinemia, erythropenia
Drug interactions
Increases the blood concentration of salicylates (increases the risk of crystalluria), ethinyl estradiol, benzylpenicillin and tetracyclines, reduces the concentration of oral cotraceptives. Reduces the anticoagulant effect of coumarin derivatives. Improves the absorption of iron preparations in the intestines. Quinoline drugs, calcium chloride, salicylates, and corticosteroids deplete vitamin C reserves when used for a long time.
Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinks reduce absorption and absorption.
Increases the overall clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body.
Barbiturates and primidone increase the excretion of ascorbic acid in the urine.
Reduces the therapeutic effect of antipsychotropic drugs (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.
Special instructions
When treating with large doses of ascorbic acid, it is necessary to monitor renal function, blood pressure(BP) and pancreatic function. Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity).
In patients with high iron levels in the body, ascorbic acid should be used in minimal doses.
Included dragee includes ascorbic acid, starch syrup, sugar, talc, light mineral oil, yellow wax, dye E104 (quinoline yellow), orange flavor.
Compound r/ra for IV and IM administration: ascorbic acid (0.05 g/ml or 0.1 g/ml), sodium bicarbonate and sulfite, water saturated with carbon dioxide for injection.
The tablets contain ascorbic acid, dextrose, sugar, potato starch, additive E470 (calcium stearate), flavoring (strawberry/raspberry/cranberry/wild berries).
Chewable tablets contain ascorbic acid, refined sugar, magnesium stearate, , microcrystalline cellulose, orange flavor, hypromellose, yellow E110 (“Sunset”) or beta-carotene.
Release form
- Dragees, packaged in 50, 100 or 200 pcs. in bottles made of polymer materials/glass jars or 10 pieces in blister packs, 5 packs in a cardboard box.
- R/R for intravenous and intramuscular administration of 5 and 10% in ampoules of 1, 2 and 5 ml, 10 ampoules in a cardboard box.
- Lyophilisate for the preparation of solution for intravenous and intramuscular administration. Dosage 0.05 g. The drug is available in ampoules, 5 ampoules in a cardboard pack complete with solvent (water for 2 ml).
- Powder for the preparation of oral solution for oral administration. Dosage 1 and 2.5 g; sold in paper bags laminated with PE.
- Tablets, packaged in 50 pcs. in glass jars.
- Chewable tablets in package No. 30.
Pharmacological action
Vitamin preparation . Ascorbic acid in its pure form.
Pharmacodynamics and pharmacokinetics
The drug has activity vitamin C. Has a metabolic effect, regulates oxidation-reduction reactions and hydrogen transport in large quantities biochemical reactions, improves the use of glucose in the citrate cycle, accelerates tissue regeneration, takes part in the formation of H4-folate, collagen And steroid hormones .
Maintains normal permeability of capillary walls and the colloidal state of the extracellular matrix. Activates proteases, participates in metabolism , pigments and aromatic amino acids, promotes the deposition of glycogen in the liver.
Due to the activation of liver cytochromes, it increases its protein-forming and detoxification activity, as well as synthesis prothrombin . Restores endocrine function schthyroid gland and exocrine - pancreas , stimulates separation bile .
Regulates immunological reactivity (activates the production , antibodies, components of the complement system C3), promotes phagocytosis and strengthening .
Renders antiallergic effect and stops inflammatory processes. Inhibits the production of mediators anaphylaxis and inflammation (including prostaglandins ), inhibits ejection histamine and accelerates its degradation.
Because in the human body vitamin C is not produced, insufficient amounts in food provoke hypo- And vitamin deficiency C .
The daily norm for men is 0.07-0.1 g, for women - 0.08 g. During pregnancy, the need increases to 0.1 g, during lactation - to 0.12 g. Children and adolescents, depending on age, should take from 0.03 to 0.07 g of vitamin C.
Absorbed in the small intestine: when taking less than 0.2 g, about 2/3 of the dose taken is absorbed; with increasing dose, absorption decreases to 50-20%.
The concentration of ascorbic acid when taken orally reaches a maximum after 4 hours.
The substance easily penetrates into And , and subsequently - into all tissues; deposited in the adrenal cortex, posterior lobe , intestinal walls, muscle tissue, brain, ovaries, interstitial cells of the seminal glands, ocular epithelium, spleen, liver, kidneys, lungs, pancreas and thyroid glands, heart.
Biotransformed mainly in the liver.
Ascorbate and its metabolites ( diketogulonic And oxaloacetic acid ) are excreted in urine and intestinal contents, and are also excreted in breast milk and sweat gland secretions.
Indications for use
The use of the drug is advisable for:
The antioxidant properties of ascorbic acid are used in the treatment , , infectious and alcoholic delirium, diffuse connective tissue lesions (SLE, , scleroderma ), overdose of anticoagulants, intoxication with barbiturates, sulfonamides, benzene, aniline, methyl alcohol, anesthesin, carbon monoxide, dichloroethane, disulfiram, hydrocyanic acid, potassium permanganate, phenols, thallium, arsenic, , aconite.
Taking the drug is also indicated during the recovery period after illnesses and surgical interventions.
Intravenously and intramuscularly Ascorbic acid in ampoules is administered in situations where it is necessary to quickly fill the deficiency vitamin C , as well as in situations where oral administration is not possible.
In particular, parenteral administration is required when Addison's disease , a number of gastrointestinal diseases (in conditions after resection of a section of the small intestine and gastrectomy , persistent diarrhea , peptic ulcer ).
Contraindications
Absolute contraindications:
- hypersensitivity;
- complicated And thrombophlebitis, venous diseases .
Conditions in which Ascorbic acid is prescribed with caution:
- fructose intolerance;
- kidney pathologies (in particular, urolithiasis - when using more than 1 g per day);
- hemochromatosis ;
- thalassemia ;
- progressive tumor diseases ;
- sideroblastic And sickle cell anemia ;
- polycythemia ;
- deficiency of the cytosolic enzyme G6PD.
In pediatrics, the restriction on the use of Ascorbic acid tablets is the age of up to 4 years. Tablets are prescribed from the age of six. Chewable tablets are not used in pediatric practice.
Side effects
From the heart, vascular and hematopoietic systems: neutrophilic leukocytosis , thrombocytosis , erythropenia , hyperprothrombinemia .
From the senses and nervous system: weakness and dizziness (with too rapid administration of ascorbic acid intravenously).
From the digestive tract: when taken orally - (when taken more than 1 g/day), irritation of the mucous membrane of the digestive canal, accompanied by nausea, diarrhea , vomiting, erosion of tooth enamel (with frequent use of chewing tablets or lozenges/tablets).
Metabolic disorders: disruption of metabolic processes, inhibition of production glycogen , overeducation adrenergic steroids , water and Na retention, hypokalemia .
From the urogenital tract: increase , formation of oxalate stones (especially with long-term intake of more than 1 g per day), damage glomerular apparatus of the kidneys .
When injected into a muscle, pain at the injection site may occur; injection into a vein may be accompanied by a feeling of heat.
The substance is a strong allergen and can provoke hypersensitivity reactions even in cases where the person does not exceed the recommended daily dose.
Reserves vitamin C are depleted with prolonged use of calcium chloride, drugs quinoline series , salicylates , corticosteroids .
Solution A.K. interacts with the majority medicines when mixed in one syringe.
Terms of sale
A prescription is required to purchase the solution. Other forms of release are available without a prescription.
Example of a recipe in Latin for a 5% solution:
Sol. Acidi ascorbinici 5% – 1 ml
D.t.d. N.10 in amp.
S. Intramuscularly, 1 ml 2 times a day.
Recipe in Latin for the tablet form of the drug:
Acidi ascorbinici 0.05
D.t.d. N. 50 in tab.
S. For 2 tables. 3 times a day after meals
Storage conditions
Ascorbic acid should be stored in a light-protected place, inaccessible to children, at a temperature of no more than 25°C.
Best before date
The solution is considered suitable for use within a year, the dragee - within a year and a half after the date of issue. The shelf life for powder, lyophilisate and chewable tablets is 2 years. Ascorbic acid in tablets retains its pharmacological properties for 3 years.
Special instructions
Wikipedia states that vitamin C (L-ascorbic acid) is an organic compound related to glucose. Its benefits for human body is huge - the vitamin functions as a coenzyme for a number of metabolic processes, an antioxidant and a reducing agent.
According to the International Pharmacopoeia, the substance has the form of an almost white or white crystalline powder with a sour taste. Easily soluble in water, soluble in ethanol (approximately 750 g/l) TS, practically insoluble in other organic solvents, the powder is practically insoluble. Belongs to the category of antiscorbutic drugs.
Vitamin C in solution it quickly collapses when exposed to air; Even in a light-protected place, it gradually collapses in a humid atmosphere. The rate of destruction increases with increasing temperature.
Ascorbic acid is present in all tissues higher plants and animals. Man, unlike most animals, in the process of evolution due to mutation, lost the ability to independently synthesize vitamin C , and receives it exclusively from food.
OKPD code for ascorbic acid ( vitamin C ) - 24.41.51.180. For the food industry, the substance is obtained in accordance with GOST 4815-76.
Quantitative determination of a substance
Methods for quantitative determination of A.c. based on its pronounced restorative properties.
The simplest, most objective and in an exact way is a method of determination based on the ability of A.K. reduce ferric ions into ferrous ions.
The amount of Fe2+ ions formed is equimolar to the amount of A.c. in the analyzed sample (the minimum amount of A.C. in the sample is 10 nmol) and is determined by the color reaction with potassium iron sulfide.
What is ascorbic acid needed for?
The substance participates in the processes of biotransformation of other , education , as well as education and exchange And norepinephrine in the medulla adrenal glands , supplies hydrogen for the formation of nuclear DNA, reduces the body’s need for B vitamins , increases the body’s immunobiological resistance, affects activity leukocytes ; improving the absorption of Fe, thereby enhancing the synthesis hemoglobin and maturation red blood cells , neutralizes toxins released by pathogenic microflora, accelerates wound healing and postoperative sutures and healing of fractures.
Ascorbic acid in urine is an important indicator of the health of the body. Small quantity vitamin C in urine may indicate malfunction internal organs or the development of a tumor process. Elevated levels of ascorbic acid may indicate an unbalanced diet and the likelihood of kidney stones.
Daily excretion rate vitamin C urine - 0.03 g. When diagnosing this indicator, we can conclude that a person receives a sufficient amount of ascorbic acid, and his body works optimally.
How many calories are in ascorbic acid?
100 grams of product contains 0.1 g of fat, 0.1 g of protein and 95.78 g of carbohydrates. This amount of carbohydrates allows you to compensate for more than a third (namely 35%*) of your daily requirement for them.
*average value is given nutritional value products from different sources. Data may vary depending on the origin of the product. The value is given for a diet that involves consuming 2 thousand kcal per day.
Calorie content of 100 grams of product is 970 kJ or 231.73 kcal.
Why is ascorbic acid useful in cosmetology?
In cosmetology, ascorbic acid is used in preparations that slow down aging, restore protective functions and healing accelerating agents.
The easiest way to use vitamin C for hair - add powder (crushed tablet) or solution to a single portion of shampoo or hair mask. Ascorbic acid should be added to care products immediately before use.
Such simple procedures can restore hair structure, prevent hair loss, and make hair soft and shiny.
For the face, ascorbic acid is most often used in powder. Before the procedure, the powder (or crushed tablets) is mixed with mineral water to form a thick paste. The product is applied to the face for 20 minutes and then washed off.
Daily rubbing with a solution of ascorbic acid diluted with mineral water in a 1:1 ratio is also beneficial for the face. You can also add the solution/powder to homemade masks.
How is ascorbic acid beneficial for athletes?
Vitamin C is a stimulator of muscle mass anabolism, which makes its use in bodybuilding appropriate. In addition, scientists were able to prove that by suppressing the process of peroxidation and secretion cortisol he also provides anti-catabolic effect . Thus, the reception vitamin C before training will protect muscles and slow down protein breakdown.
Upon completion of the course anabolic steroids ascorbic acid is taken as a component of PCT (post-cycle therapy).
Ascorbic acid to induce menstruation
High doses vitamin C prevent entry progesterone into the uterus, so Ascorbic acid is often taken when menstruation is late.
However, doctors do not advise abusing this method. Firstly, repeated use of ascorbic acid can cause problems with the gastrointestinal tract. Secondly, taking pills can make it difficult to diagnose the causes of menstrual irregularities and further treatment.
Precautions
Too rapid intravenous administration of ascorbic acid solution should be avoided. If long-term use of the drug is necessary, monitoring of blood pressure, renal function, and glucose levels is necessary.
Ascorbic acid alters laboratory test results.
Analogs
Additiva Vitamin C , Asvitol , Ascovit , Vitamin C , Vitamin C-injectopas , Rostvit , Setebe 500 , Cevicap , Celascon Vitamin C , Citravit , (+ Ascorbic acid).
For weight loss
Ascorbic acid does not reduce the amount of subcutaneous fat and cannot eliminate the consequences of an unbalanced diet and inactive lifestyle, so using it as an independent means for losing weight is not advisable.
However, vitamin C is by no means an unnecessary addition to the diet of those losing weight, because it helps strengthen the immune system, improve overall well-being in chronic diseases and more quickly restore muscles after physical activity.
Can pregnant women take ascorbic acid?
The minimum requirement for ascorbic acid during pregnancy is approximately 0.06 g/day. (in the 2nd and 3rd trimesters). It is important to consider that the fetus can adapt to increased doses taken by a woman. vitamin C . The consequence of this may be withdrawal syndrome in the newborn.
In accordance with the FDA classification, injectable forms of ascorbic acid belong to group C on the scale of possible risks to the fetus. The administration of the solution can be prescribed to a pregnant woman only if absolutely necessary.
Use of high doses vitamin C for intravenous administration during pregnancy can cause miscarriage.
The minimum requirement during breastfeeding is 0.08 g/day. Theoretically, there are certain risks for the child when a nursing woman uses too high doses vitamin C .
Vitamin C plays a vital role in the human body, but is not produced independently. Therefore, it is so important to remember that ascorbic acid, whether it be a pill, tablet or powder, should be an integral element in home medicine cabinet. The vitamin helps maintain the body's strength and serves as a preventative against colds and infectious diseases.
Our health is affected by many negative factors: poor environmental conditions, high levels of heavy metals in the air and water, poor nutrition, bad habits, chronic diseases, hormonal imbalances, everyday stress and a sedentary lifestyle. All these points reduce immunity, disrupt the proper functioning of the cardiovascular system, cause digestive problems and worsen well-being. Individuals who regularly take it help their body cope with illnesses on its own and protect themselves from health complications in the future.
Indications for the use of vitamin C in tablets
When treating many diseases, doctors prescribe medications containing vitamin C to support immunity.
Let's take a closer look at why ascorbic acid tablets are useful and in what cases they are prescribed:
- Avitaminosis and hypovitaminosis of vitamin C . Pathological condition of the body associated with poor nutrition and eating foods low in vitamins. Also, impaired absorption of the vitamin may be associated with diseases of the gastrointestinal tract and the body’s inability to absorb the beneficial element.
- Prevention of infectious and colds . During the off-season, there is a high probability of becoming infected or getting sick from hypothermia. Ascorbic acid in this case is an immunomodulatory drug and protects the body from diseases.
- Bleeding. With increased pressure, thin capillaries cannot withstand the load and burst, which may cause nosebleeds. Ascorbic acid in tablets strengthens blood vessels and improves blood composition.
- Hemorrhagic diathesis . Symptoms of the disease are expressed in the appearance of hematomas on the body. Hemorrhages occur due to blood clotting disorders and fragile blood vessels. Vitamin C improves the condition of the cardiovascular system and restores the walls of blood vessels.
- Dystrophy. The disease is accompanied by vitamin deficiency and deficiency vitality. For treatment, complex therapy is prescribed, aimed at increasing immunity.
- Poisoning. In case of intoxication, doctors always recommend urgently taking lemon juice or lemon water. Due to the high content of ascorbic acid in the fruit, the body is quickly cleansed of toxins and waste. The vitamin has an antioxidant effect and removes harmful substances.
- Physical and mental stress . Any trainer will confirm that when playing sports you should take ascorbic acid in tablets. The element promotes muscle tone, helps bodybuilders quickly build muscle mass, and also strengthens the circulatory system, which is subject to heavy loads among athletes. For people whose activities involve mental stress, vitamin C helps supply oxygen to the brain and improves memory and attention.
- Liver diseases. With a lack of vitamin C, metabolism is disrupted and local immunity is reduced. Ascorbic acid promotes tissue regeneration, which is necessary for the normal functioning of the main “filter” of our body.
As can be seen from the above, vitamin C is an essential element for the proper functioning of the body. You can always take ascorbic acid with you to work and take it right time. Thanks to the affordable cost of the drug, people with any level of income can afford to take the pill.
Beneficial properties of ascorbic acid
Vitamin C is found in many foods (rose hips, green salad, kohlrabi, parsley, onions, bell pepper, grapefruit, black currant, lemon, etc.), but does not always enter the body in required quantity. Meanwhile, this element is very important, its deficiency must be replenished.
Ascorbic acid has a beneficial effect on the functioning of the nervous system, restores connections between neurotransmitters, thereby improving memory and attention, therefore it is recommended that students drink additional vitamins while preparing for exams. The vitamin is also involved in hematopoiesis and allows the absorption of iron, which is responsible for the normal level of hemoglobin in the blood. Ascorbic acid restores intestinal function and normalizes metabolism. Acid helps remove excess fluid from the body and eliminates swelling of tissues. The drug is useful as a preventative against strokes, as it thins the blood, prevents the formation of blood clots and strengthens blood vessels.
Representatives of the fair sex have always resorted to various tricks to keep their figures in good shape. It’s much easier, since it stimulates the production of hormones that are responsible for the fat burning process. Many women use ascorbic acid in tablets to prepare anti-aging masks. Thanks to its regenerating functions, the acid smooths out wrinkles, eliminates signs of fatigue and relieves skin irritation.
Instructions for use of vitamin C tablets
Ascorbic acid in dragees is small yellow balls with a sour taste. Before starting a course of taking the vitamin, you should consult with your doctor and find out how to take it.
Different dosages are prescribed for children and adults depending on the condition:
- To prevent ARVI, children over 5 years of age should take 1 tablet per day, adults - 2 tablets per day.
- For treatment, adults are recommended to drink 2 tablets three to five times a day, children - 2 tablets three times a day.
Vitamins should be taken on a full stomach to avoid side effects such as burning and pain in the stomach. There are some contraindications to the use of ascorbic acid. Patients with thrombophlebitis, renal failure, diabetes mellitus, people with a deficiency of sucrose, isomaltase, fructose, as well as people with blood diseases, therapy with the vitamin is contraindicated.
? In case of overdose, children and adults may experience the following symptoms:
- heartburn;
- stomach pain;
- intestinal dysfunction;
- headaches;
- sleep disturbance;
- nausea;
- increased blood sugar levels.
To avoid the development of side effects, including, you should carefully study the information about the benefits and harms of ascorbic acid in tablets, which is contained in the instructions for use.
Recipes using vitamin C
There is no ascorbic acid in products of animal origin. If you want to maintain your immune system and eat healthy, you should eat vitamin-rich vegetables and fruits. Salad from and, dressed olive oil, is not only useful, but also delicious dish for the whole family. Sauerkraut Since ancient times it has been famous for its benefits for digestion. Scientists have proven that sauerkraut contains several times more vitamin C than fresh cabbage. Many doctors recommend using this product for those who want to lose weight.
In the autumn season, you need to support your immune system; cranberry juice with lemon serves great solution. To prepare a “live” drink, pour hot boiled water and let the fruit drink brew for half an hour. All without boiling beneficial properties the berries are preserved in the drink.
Ascorbic acid can also be used in the preparation of whitening face masks and healthy hair balms. It's no secret that collagen maintains youthful and elastic skin. To prepare a rejuvenating mask, mix one teaspoon of gelatin, one vitamin C tablet and dilute with one spoon of water. Heat the resulting mixture in microwave oven for 10 seconds and apply the product to a previously cleansed face. After 15 minutes, remove the mask. This procedure will rejuvenate the skin, saturate it with collagen, and thanks to ascorbic acid, eliminate inflammation, rashes and age spots on the face.
To normalize the functioning of the sebaceous glands of the scalp and restore damaged hair structure, you can use vitamin C pills to prepare balms. The most common recipe is an egg mask. Mix the yolk of one egg with burdock oil, add one ascorbic acid tablet. Rub the mask into the roots of your hair. According to consumer reviews, hair after the procedure becomes soft, manageable and silky. Many women noted that after a course of treatment with such a mask, the oiliness of their hair decreases, and they can wash their hair much less often.
Be attentive to your health and consult a doctor promptly. It is easier to prevent a disease than to treat it later and spend money on expensive drugs. Ascorbic acid is an excellent means of preventing many diseases.
Ascorbic acid (Vitamin C) is a drug in the form of pills, widespread since Soviet times, which is familiar to every family under the name “ascorbic acid”. A person cannot synthesize this vitamin, so the necessary supply in the body is replenished with food intake. The drug is obtained synthetically.
Ascorbic acid is a drug common since Soviet times, which is familiar to every family under the name “ascorbic acid”.
International nonproprietary name
On Latin the drug is called Acidum ascorbinicum.
ATX and registration number
ATC code A11GA01 Vitamin C. Registration number LP-001641 dated 04/09/12
Pharmacotherapeutic group
Ascorbic acid belongs to the group of water-soluble substances. Vitamin preparations are especially important in old age, for pregnant women, under increased stress, for children during rapid growth when the process of tissue regeneration occurs, etc.
Mechanism of action
Has activity: antioxidant, regulating redox processes, metabolic, replenishing vitamin C deficiency.
Participating:
- in the functioning of enzymes that play an important role in the formation of collagen (catalyze the hydroxylation of lysine and proline);
- in the formation of norepinephrine;
- V metabolic processes cholesterol, catecholamines and steroid hormones.
Absorbed in the gastrointestinal tract (mainly in the jejunum), and excreted by the kidneys, through the intestines, with sweat, breast milk unchanged and in the form of metabolic products.
Compound
The active ingredient is vitamin C. Available in the form of dragees, 1 pc. which also contains a certain amount of auxiliary substances: starch molasses, sugar, wax, mineral oil, talc, fruit flavorings.
Package
Dragee is packaged in a polymer jar of 100 or 200 pieces, and then in a cardboard box.
What are the benefits of Ascorbic acid?
For alcoholism
Ascorbic acid is actively used in the complex, because it promotes the removal of alcohol from the body and protects.
Treatment is combined with psychotherapy and a complete ban on drinking alcohol.
Treatment takes place in 2 stages:
- At the first stage, it is carried out, in which vitamin C is used together with other drugs. Tranquilizers are often prescribed. The patient is given plenty of mineral waters, juices, compotes and diuretics. Provide enhanced nutrition.
- When a good state, mental and somatic, is achieved, stage 2 is carried out - anti-alcohol treatment using one of the following methods:
- conditioned reflex therapy;
- therapy;
- group rational therapy;
Upon discharge, the doctor tells you what to do to avoid a breakdown - a return to drinking.
For a hangover
Alcohol compatibility
Ascorbic acid increases and accelerates the elimination of ethanol from the body, which, in turn, reduces the concentration of acid in the body. May affect the effectiveness of treatment.
Conditions for dispensing from pharmacies
Over-the-counter release.
Price
A jar of 50 mg tablets of Ascorbic acid costs 20-25 rubles, and a package of 25 mg tablets, which contain glucose, costs about 10-20 rubles.
Storage conditions
The drug is stored in a dry place, protected from light and out of reach of children, at temperatures up to 25°C.